Antivirals
Pan-family, mutation resistant
Inhibitors of viral activity
The recent pandemic has driven home the importance of orally available antivirals within the response arsenal. We are looking at a variety of conserved, functionally relevant pockets within viral familes identified as potential sources of the next global pandemic. We are identifying molecules that could be active across these families and would be resistant to variants and mutants that tend to weaken drug binding
Flavivirus
This family consist of various pathogenic viruses that include Dengue, West Nile Virus, Japanese encephalitis etc. With global warming the insect vectors that carry these diseases are also expanding their geography, thereby opening up the possibility of global pandemics. We are targeting two validated, conserved enzyme targets within the Flaviviridae proteome. The program is currently at the design stage.
