To bring our designed novel biologics to life we use the Pichia Pastoris system for protein expression. Pichia is a methylotrophic yeast that is able to use methanol as a carbon source to express the protein of interest. The ability of the system to produce high-yields of secreted fully folded proteins combined with our in-house expertise makes this a powerful addition to our technology collection.
Our construct design expertise coupled with our proprietary protocols for the selection of robust, high-yielding, and methanol tolerant clones ensures that the cell banks created at this step are assets that can actually be used to make the desired biologic at scale.
Quick and efficient make/test cycles are critical for the success of any discovery / development program. The team’s expertise with the Pichia system coupled with the vast experience in protein production allow us to rapidly develop working processes at lab-scale to produce purified material for characterization
Sekkei’s team consists of successful product developers who taken assets all the way to the market. Our in-house experiences allow us to create entire roadmaps all the way from initial clone design to large-scale commercial production using Pichia pastoris.
Our construct design expertise coupled with our proprietary protocols for the selection of robust, high-yielding, and methanol tolerant clones ensures that the cell banks created at this step are assets that can actually be used to make the desired biologic at scale.
Quick and efficient make/test cycles are critical for the success of any discovery / development program. The team’s expertise with the Pichia system coupled with the vast experience in protein production allow us to rapidly develop working processes at lab-scale to produce purified material for characterization
Sekkei’s team consists of successful product developers who taken assets all the way to the market. Our in-house experiences allow us to create entire roadmaps all the way from initial clone design to large-scale commercial production using Pichia pastoris.
